导师简介--丁妍

出生年月

1979年2月

单位

湖北医药学院生物医学工程学院/附属太和医院

所属学科

医学技术-检验技术

职称、职务

教授，硕士研究生导师，胚胎干细胞研究湖北省重点实验室副主任

E-mail

dyywzx@163.com

联系方式（办公电话）

15971878430

研究方向

1.心血管疾病发病机制研究

2.干细胞与衰老相关疾病研究

个人简介

（可包含个人履历、学术任职与荣誉、科研项目、代表性成果等，500字左右，代表性项目和成果不计入总字数）

博士，教授，硕士生导师，现任胚胎干细胞研究湖北省重点实验室副主任。湖北医药学院学报青年编委，中整协干细胞与整形美容分会委员，主持国家、省部级等各类项目共计10余项，其中国家自然科学基金项目3项；作为骨干参与国家科技部重大专项子项目、国家基础研究计划“973”、湖北省重大专项、湖北省科技厅创新群体等项目。近年来一直从事干细胞与肿瘤及心血管相关领域基础和临床应用研究，积累了大量经验，发表SCI论文30余篇，其中以第一作者或通讯作者发表SCI论文20余篇；获省、市级科技进步奖5项。

代表作引文格式参考GB/T 7714-2015，示例如下：

近年代表性论文（*通信作者，^#共同第一作者）和奖励：

1. Ji R, Wei L, Zan Y, Li X, Ma S, Ma L, He X, Wang L,Ding Y. ABI3BP promotes renal aging through Klotho-mediated ferroptosis. J Transl Med. 2024 May 29;22(1):514.

2.Wang Y, Zan Y, Huang Y, Peng X, Ma S, Ren J, Li X, Wei L, Wang X, Yuan Y, Tang J, Zhan Z, Wang Z, Ding Y*. NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress. Cell Death Discov. 2023 Feb 4;9(1):43.

3. Yingying Huang, Xiao Li, Lin Wei, Shinan Ma, Liming Ma, Yuxin Zan, Xiju He, Yijun Tang andYan Ding. NSUN2 relies on ALYREF to regulateNrf2-mediated oxidative stress and alleviateDox-induced liver injury. Biology Direct, 2024, 19:32.

4.Xinxia Luo; Junyang Zhou; Zhixiao Wang; Yun He; Li Yu; Shinan Ma; Shan Wang; Xiaoli Wang;Yahong Yuan; Dongshen Li; Taixin Cui;Yan Ding ; An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction, life sciences , 2020, 259: 118199.

5.Junyang Zhou; Zhixiao Wang; Yun He; Xinxia Luo; Wenjun Zhang; Li Yu; Xiuying Chen; Xiju He; Yahong Yuan; Xiaoli Wang; Xingrong Guo; Junming Tang; Mingan Zhu; Dongshen Li;Yan Ding.  Qiliqiangxin reduced cardiomyocytes apotosis and improved heart function in infarcted heart through Pink1/Parkin -mediated mitochondrial autophagy,  BMC Complementary Medicine and Therapies , 2020, 20(1): 203.

6. Wei L, Yang X, Wang J, Wang Z, Wang Q,Ding Y#, Yu A#. H3K18 lactylation of senescent microglia potentiates brain aging and Alzheimer's disease through the NFκB signaling pathway. J Neuroinflammation. 2023 Sep 11;20(1):208.

7. Wang X, Tu Q, Mao A, Meng K, Lv J, Li B, Zhang T, Zhang H, Ding Y#, Cao Z#. Biochanin A alleviates endothelial cell senescence via epigenetic regulation of the HDAC1/H3K4me3/NFKB1 axis. Phytomedicine. 2025 Oct 13;148:157385.

8. Mao A, Tu Q, Xie H, Wang X, Liu Y,Ding Y#, Cao Z#. ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway. Mech Ageing Dev. 2025 Aug 30;228:112104.

9. Wu Y, Huang X, He Y, Chang J, Fang X, Kang P, Feng N, Liu R, Xiao P, Shi D, Zhang Q, Ding Y, Zhang W, He X. Mechanism of puerarin alleviating myocardial remodeling through NSUN2-mediated m5C methylation modification. Phytomedicine. 2025 Jul 25;143:156849.

10. Li B, Zhao X, Hong Z,Ding Y#, Zhang Y#. Circulating immune cell phenotyping is potentially relevant for diabetic retinopathy risk assessment. Diabetes Res Clin Pract. 2024 May;211:111667.

11.Chen X, Yu L, Zhou J, Ren J, Wang S, Tan Y,Ding Y*. Inhibition of p62 and/or NFE2L2 induced autophagy impaires esophageal squamous cell cancer metastasis by reversing EMT. Gene. 2023 Mar 30;858:147194.

12.Ren J, Chen X, Li J, Zan Y, Wang S, Tan Y, Ding Y*. TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy. Epigenetics. 2024 Dec;19(1):2323751. 

13. Zan Y, Ding Y#. Pancancer Analysis of NSUN2 with a Focus on Prognostic and Immunological Roles in Endometrial Cancer. Reprod Sci. 2024 Jun 20. doi: 10.1007/s43032-024-01625-5. Epub ahead of print.